USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P98082 USC-OGP 2-DE database:  P98082 P98082 General information about the entry View entry in simple text format Entry name DAB2_HUMAN Primary accession number P98082 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Disabled homolog 2; AltName: Full=Adaptor molecule disabled-2; AltName: Full=Differentially expressed in ovarian carcinoma 2; Short=DOC-2; AltName: Full=Differentially-expressed protein 2;. Gene name Name=DAB2 Synonyms=DOC2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1111: pI=5.20; Mw=104418 Cross-references UniProtKB/Swiss-Prot P98082; DAB2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name DAB2_HUMAN Primary accession number P98082 Secondary accession number(s) A6NES5 Q13598 Q9BTY0 Q9UK04 Sequence was last modified on  April 17, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 164) Name and origin of the protein Description RecName: Full=Disabled homolog 2; AltName: Full=Adaptor molecule disabled-2; AltName: Full=Differentially expressed in ovarian carcinoma 2; Short=DOC-2; AltName: Full=Differentially-expressed protein 2; Gene name Name=DAB2 Synonyms=DOC2 Encoded on Name=DAB2; Synonyms=DOC2 Keywords 3D-structure; Acetylation; Alternative splicing; Apoptosis; Coated pit; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Developmental protein; Differentiation; Endocytosis; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport; Tumor suppressor; Wnt signaling pathway. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U39050; AAC50824.1; -; mRNA EMBL AH003698; AAB19032.1; -; Genomic_DNA EMBL U53446; AAA98975.1; -; mRNA EMBL AF188298; AAF05540.1; -; mRNA EMBL AF205890; AAF23161.1; -; Genomic_DNA EMBL AC008916; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471119; EAW55989.1; -; Genomic_DNA EMBL BC003064; AAH03064.1; -; mRNA EMBL L16886; AAA93195.1; -; mRNA CCDS CCDS34149.1; -. [P98082-1]; . CCDS CCDS58946.1; -. [P98082-3]; . PIR G02228; G02228; . RefSeq NP_001231800.1; NM_001244871.1. [P98082-3]; . RefSeq NP_001334.2; NM_001343.3. [P98082-1]; . UniGene Hs.696631; -; . PDB 2LSW; NMR; -; A=24-58 PDBsum 2LSW; -; . ProteinModelPortal P98082; -; . SMR P98082; -; . BioGrid 107971; 94; . DIP DIP-45617N; -; . IntAct P98082; 57; . MINT MINT-5006053; -; . STRING 9606.ENSP00000313391; -; . iPTMnet P98082; -; . PhosphoSitePlus P98082; -; . BioMuta DAB2; -; . DMDM 145559465; -; . EPD P98082; -; . MaxQB P98082; -; . PaxDb P98082; -; . PeptideAtlas P98082; -; . PRIDE P98082; -; . DNASU 1601; -; . Ensembl ENST00000320816; ENSP00000313391; ENSG00000153071. [P98082-1]; . Ensembl ENST00000339788; ENSP00000345508; ENSG00000153071. [P98082-2]; . Ensembl ENST00000509337; ENSP00000426245; ENSG00000153071. [P98082-3]; . Ensembl ENST00000545653; ENSP00000439919; ENSG00000153071. [P98082-3]; . GeneID 1601; -; . KEGG hsa:1601; -; . UCSC uc003jlw.4; human. [P98082-1]; . CTD 1601; -; . DisGeNET 1601; -; . GeneCards DAB2; -; . HGNC HGNC:2662; DAB2; . HPA CAB009314; -; . HPA HPA028888; -; . MIM 601236; gene; . neXtProt NX_P98082; -; . OpenTargets ENSG00000153071; -; . PharmGKB PA27132; -; . eggNOG KOG3535; Eukaryota; . eggNOG ENOG410XZ1H; LUCA; . GeneTree ENSGT00520000055585; -; . HOGENOM HOG000060158; -; . HOVERGEN HBG018945; -; . InParanoid P98082; -; . KO K12475; -; . OMA IPQENAD; -; . OrthoDB EOG091G0382; -; . PhylomeDB P98082; -; . TreeFam TF316724; -; . Reactome R-HSA-190873; Gap junction degradation; . Reactome R-HSA-196025; Formation of annular gap junctions; . Reactome R-HSA-8856825; Cargo recognition for clathrin-mediated endocytosis; . Reactome R-HSA-8856828; Clathrin-mediated endocytosis; . SignaLink P98082; -; . SIGNOR P98082; -; . ChiTaRS DAB2; human; . GeneWiki DAB2; -; . GenomeRNAi 1601; -; . PRO PR:P98082; -; . Proteomes UP000005640; Chromosome 5; . Bgee ENSG00000153071; -; . CleanEx HS_DAB2; -; . ExpressionAtlas P98082; baseline and differential; . Genevisible P98082; HS; . GO GO:0005905; C:clathrin-coated pit; IDA:UniProtKB; . GO GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB; . GO GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0001650; C:fibrillar center; IDA:HPA; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0005765; C:lysosomal membrane; TAS:Reactome; . GO GO:0005730; C:nucleolus; IDA:HPA; . GO GO:0005886; C:plasma membrane; IDA:HPA; . GO GO:0038024; F:cargo receptor activity; IMP:UniProtKB; . GO GO:0035615; F:clathrin adaptor activity; IMP:UniProtKB; . GO GO:0008022; F:protein C-terminus binding; IPI:UniProtKB; . GO GO:0046332; F:SMAD binding; IDA:UniProtKB; . GO GO:0006915; P:apoptotic process; IEA:UniProtKB-KW; . GO GO:0008283; P:cell proliferation; TAS:ProtInc; . GO GO:0035026; P:leading edge cell differentiation; IMP:UniProtKB; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW; . GO GO:0060766; P:negative regulation of androgen receptor signaling pathway; IMP:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:BHF-UCL; . GO GO:0032091; P:negative regulation of protein binding; IMP:BHF-UCL; . GO GO:1903077; P:negative regulation of protein localization to plasma membrane; IMP:UniProtKB; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IMP:BHF-UCL GO GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB; . GO GO:2000370; P:positive regulation of clathrin-dependent endocytosis; IMP:UniProtKB; . GO GO:2000643; P:positive regulation of early endosome to late endosome transport; IMP:UniProtKB; . GO GO:0045807; P:positive regulation of endocytosis; IMP:UniProtKB; . GO GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IDA:UniProtKB; . GO GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:UniProtKB; . GO GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:BHF-UCL; . GO GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL; . GO GO:0060391; P:positive regulation of SMAD protein import into nucleus; IDA:UniProtKB; . GO GO:0045893; P:positive regulation of transcription; DNA-templated; IMP:BHF-UCL GO GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB; . GO GO:2000096; P:positive regulation of Wnt signaling pathway; planar cell polarity pathway; IMP:BHF-UCL GO GO:0015031; P:protein transport; IEA:UniProtKB-KW; . GO GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW; . Gene3D 2.30.29.30; -; 1; . InterPro IPR011993; PH_dom-like; . InterPro IPR006020; PTB/PI_dom; . Pfam PF00640; PID; 1; . SMART SM00462; PTB; 1; . SUPFAM SSF50729; SSF50729; 1; . PROSITE PS01179; PID; 1; .

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